PIPERAZINE HYDRATE
Piperazine hexahydrate
CAS: 142-63-2
Molecular Formula: C4H22N2O6
PIPERAZINE HYDRATE - Names and Identifiers
| Name | Piperazine hexahydrate |
| Synonyms | parid arpezine vermisol usafa-3803 arthriticine PIPERAZINE HYDRATE Piperazine hydrate PIPERAZINE HEXAHYDRATE Piperazine hexahydrate Piperazine hyexahydrate DIETHYLENEDIAMINE HEXAHYDRATE |
| CAS | 142-63-2 |
| EINECS | 604-300-8 |
| InChI | InChI=1/C4H10N2.6H2O/c1-2-6-4-3-5-1;;;;;;/h5-6H,1-4H2;6*1H2 |
| InChIKey | AVRVZRUEXIEGMP-UHFFFAOYSA-N |
PIPERAZINE HYDRATE - Physico-chemical Properties
| Molecular Formula | C4H22N2O6 |
| Molar Mass | 194.23 |
| Density | 1.2903 (rough estimate) |
| Melting Point | 42-44°C(lit.) |
| Boling Point | 145-156°C(lit.) |
| Flash Point | 190°F |
| Water Solubility | almost transparency |
| Vapor Presure | 0.8 mm Hg ( 20 °C) |
| Appearance | Crystalline Powder or Flakes |
| Color | White or transparent |
| Exposure Limit | ACGIH: TWA 0.03 ppm |
| Merck | 14,7464 |
| BRN | 4455527 |
| Storage Condition | 2-8°C |
| Refractive Index | 1.4800 (estimate) |
| Physical and Chemical Properties | White crystals. |
| Use | For the synthesis of pharmaceuticals and organic compounds |
PIPERAZINE HYDRATE - Risk and Safety
| Risk Codes | R34 - Causes burns R42/43 - May cause sensitization by inhalation and skin contact. R52/53 - Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment. R62 - Possible risk of impaired fertility R63 - Possible risk of harm to the unborn child |
| Safety Description | S22 - Do not breathe dust. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
| UN IDs | UN 2579 8/PG 3 |
| WGK Germany | 1 |
| RTECS | TM0850000 |
| TSCA | Yes |
| HS Code | 29335990 |
| Hazard Class | 8 |
| Packing Group | III |
PIPERAZINE HYDRATE - Nature
Open Data Verified Data
White Crystal, easy to absorb moisture. Melting point 44. Boiling point 125~130 deg C. Soluble in water and ethanol, insoluble in ether, its aqueous solution was weak alkaline reaction. With the distillation of zinc, namely the formation of piperazine. Flash point 87.
Last Update：2025-06-10 22:55:16
PIPERAZINE HYDRATE - Preparation Method
Open Data Verified Data
piperazine hexahydrate was prepared from chloroethanol by ammoniation and ring synthesis of piperazine hydrochloride followed by neutralization with sodium hydroxide.
Last Update：2022-01-01 10:53:35
PIPERAZINE HYDRATE - Application
Open Data Verified Data
This product is mainly used for the production of intestinal insect drug piperazine phosphate, piperazine citrate, and fluphenazine, strong pain, rifampicin. Piperazine hexahydrate is dissolved in ethanol, and acetic acid is added to stir and cool to precipitate piperazine acetate, which can be used to synthesize hormone drug prednisolone sodium phosphate. Piperazine hexahydrate can also be used in the production of acetylpiperazine pharmaceutical intermediates. Piperazine is also used in the production of wetting agents, emulsifiers, dispersants and other surfactant products, the production of antioxidants, preservatives, stabilizers, plastic processing aids and rubber additives.
Last Update：2025-08-19 16:24:40
PIPERAZINE HYDRATE - Safety
Open Data Verified Data
- low toxicity, rat oral LD50 1900mg/kg, mouse oral LD50 11200mg/kg. The maximum allowable concentration in air is 5 mg/m3 (adipate).
- The liner is a plastic bag, and the jacket is packed in a plastic barrel, which should be sealed to prevent moisture absorption. Storage and transportation should be protected from rain, sun protection, fire. According to the general provisions of the storage and transportation of chemicals.
Last Update：2022-01-01 10:53:36
PIPERAZINE HYDRATE - Reference Information
| Introduction | piperazine (hexahydrate) belongs to heterocyclic organic compounds, which can be used in the synthesis of pharmaceuticals and organic compounds. |
| Application | used in the synthesis of pharmaceuticals and organic compounds used in the synthesis of nifuroperazone (Nifurpipone), rifampicin and acetylpiperazine and other drugs. used in the pharmaceutical, shipbuilding and plastics industries. |
| production method | piperazine hexahydrate was prepared by ammoniation and ring synthesis of piperazine hydrochloride from chloroethanol, followed by neutralization with sodium hydroxide, the reaction formula is as follows: |
Last Update：2024-04-10 22:29:15
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Product Name: Piperazine hexahydrate Request for quotation
CAS: 142-63-2
Tel: 0513-66814854
Email: pules.cn@gmail.com
Mobile: +86-17551318830
CAS: 142-63-2
Tel: 0513-66814854
Email: pules.cn@gmail.com
Mobile: +86-17551318830
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Product Name: Piperazine hexahydrate Request for quotationCAS: 142-63-2
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Product Name: Piperazine hexahydrate Request for quotationCAS: 142-63-2
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Product Name: Piperazine hexahydrate Visit Supplier Webpage Request for quotationCAS: 142-63-2
Tel: +86-400-900-4166
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Mobile: +86-18621343501
QQ: 2881950922
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